Keywords: Molecular Imaging, DSC & DCE Perfusion, Magnetic resonance angiographyTimely evaluating the abundance of vessels and infiltration by noninvasive ways together with synchronous photothermal therapy (PTT) still faces great challenges. A multifunctional and biocompatible nanoprobes (NaBiF4: Gd@PDA@PEG) with high longitudinal relaxation rate and photothermal conversion efficiency was designed as promising photosensitizer for tumor PTT and contrast agent for MR imaging. The anatomic decrease and thinning of tumor blood vessels could be observed in real-time using noninvasive MR angiography ( TRICKS and DSC-PWI) during PTT. We demonstrated that the vascular invasion status of tumor during PTT can be monitored by utilizing our multifunctional nanoprobes, which provide possibility for clinical transformation.
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