Keywords: Spectroscopy, Quantitative Imaging, PM2.5PM2.5 has been shown to be harmful to the central nervous system of mammals. Long term exposure to PM2.5 may cause changes in brain neural metabolites. However, there were few magnetic resonance spectroscopy (MRS) studies in rodents under PM2.5 exposure. In this work, we developed an air enrichment system to concentrate PM2.5. Using 1H-MRS, we successfully observed the brain metabolic profile of olfactory bulb in PM2.5-exposed mice, and found the concentration changes of some key metabolites in the brain, indicating that PM2.5 has a non-negligible impact on brain metabolism.
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