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Abstract #3766

The effectiveness of the volume transfer constant (Ktrans) as an aid to regional segmentation of nasopharyngeal tumors

Junhui Huang1,2, Zhou Liu3, Liyan Zou3, Yingying Chen3, Zhanli Hu4, Dong Liang4, Xin Liu4, Hairong Zheng4, and Na Zhang4
1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, ShenZhen, China, 2Faculty of Information Engineering and Automation, Kunming University of Science and Technology, Kunming, China, 3Department of Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China, 4Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

Synopsis

Keywords: Segmentation, Machine Learning/Artificial Intelligence

Accurate segmentation of nasopharyngeal tumor lesions from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) facilitates subsequent diagnosis and treatment. However, current segmentation methods do not incorporate the pathological properties of the tumor. Therefore, this paper proposes a multimodal DCE-MRI segmentation method that uses the pharmacokinetic features of NPC, Ktrans, as modal information to assist nasopharyngeal tumor segmentation. We validated our method in several classical deep learning segmentation networks, and DCE-MRI with fused Ktrans eigenmodes had higher Dice coefficients than DCE-MRI with a single modality. The best segmentation results were obtained by this method on the ResUNet model (dice=74.39).

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