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Abstract #3794

Higher-order diffusion MRI data acquired in clinical settings: what are the pitfalls, and how to correct them?

Jenny Chen1, Benjamin Ades-Aron1, Saurabh Maithani1, Yvonne Lui1, Dmitry S. Novikov1, Jelle Veraart1, and Els Fieremans1
1New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Data Acquisition, Diffusion/other diffusion imaging techniques, Clinical Translation, DKIMulti-shell diffusion MRI (dMRI) opens up the opportunity for microstructure mapping, but is not routinely acquired in clinics. This study retrospectively analyzed a large diffusion kurtosis imaging (DKI) dataset (N=7984) acquired as multi-series in the clinic and proposes a workflow to inspect the data before preprocessing. Automated analysis of dicom headers shows about 36% with incomplete acquisition, likely due to time constraints and patient discomfort, and 32% with image discrepancies. Finally, we show that signal variations between series occur and need to be corrected for in preprocessing. Our results indicate higher-order dMRI in the clinical setting is feasible.

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Keywords