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Abstract #3801

Three-Dimensional Multifrequency MR Elastography: clinical application for Chronic Kidney Disease

Shan Pi1, Jonathan M. Scott2, Yin Li3, Huiquan Wen1, Matthew C. Murphy2, Jingbiao Chen1, Meng Yin2, Jun Chen4, Kevin J Glaser2, Richard L Ehman2, Hui Peng3, and Jin Wang1
1Department of Radiology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, 2Department of Radiology, Mayo Clinic, Rochester, MN, United States, 3Department of Nephrology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, 4Department of Radiology, The Third Affiliated Hospital, Sun Yat-sen University (SYSU), Guangzhou, China

Synopsis

Keywords: Kidney, ElastographyChronic kidney disease (CKD) is increasing in incidence and prevalence worldwide around the world, and early detection of CKD is a major challenge. MR elastography (MRE) is a noninvasive technique capable of quantifying the mechanical properties of tissue that has shown potential for assessing kidney diseases. Our results showedthe stiffness and damping ratio were significantly correlated with eGFR and biopsy score in CKD patients. The stiffness and damping ratio also decreased along with the progression of CKD. MRE using 60-Hz and 90-Hz vibration frequencies can provide potential quantitative biomarkers for evaluating kidney function and pathological injury in CKD patients.

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