Abstract #3804
Restricted Water Diffusion in the Renal Cortex is Associated with Early Developmental Factors and Elevated Urinary Cytokines in Preadolescents
Navin Michael1, Liangjian Lu2, Delicia Shu Qin Ooi3, Chang-Yien Chan2,3, Kashthuri Thirumugan1, Suresh Anand Sadananthan1, Pottumarthi V. Prasad4, Marielle Fortier5, See Ling Loy6,7, Tan Kok Hian8,9, Fabian Yap7,10,11, Yap Seng Chong12, Keith Godfrey13, Peter Gluckman14, Johan G. Eriksson12,15,16, Yung Seng Lee3, Karen Moritz17, Shiao-Yng Chan12, Mary Wlodek1,18,19, and S. Sendhil Velan1
1Singapore Institute for Clinical Sciences, Singapore, Singapore, 2Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore, 3Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 4Department of Radiology, NorthShore University Health System, Evanston, IL, United States, 5Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore, Singapore, 6Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore, 7Duke-NUS Medical School, Singapore, Singapore, 8Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore, Singapore, 9Academic Medicine, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore, 10Department of Pediatrics, KK Women's and Children's Hospital, Singapore, Singapore, 11Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore, 12Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 13MRC Lifecourse Epidemiology Centre and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, 14Liggins Institute, University of Auckland, Auckland, New Zealand, 15Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland, 16Folkhälsan Research Center, Helsinki, Helsinki, Finland, 17School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Australia, 18School of Molecular Sciences, The University of Western Australia, Crawley, Australia, 19Obstetrics and Gynaecology, University of Melbourne, Parkville, Australia
Synopsis
Keywords: Kidney, Diffusion/other diffusion imaging techniques, Intravoxel Incoherent Motion Imaging, Renal InflammationDevelopmental factors that impair nephrogenesis can increase risk for chronic kidney disease (CKD). The early stages of CKD are characterized by an increased infiltration of inflammatory cells into the renal interstitium, which can restrict the molecular diffusion of water. We found that maternal gestational diabetes and preterm birth were associated with 2-fold and 4-fold higher risk of having restricted water diffusion (IVIM diffusion coefficient < 10th centile) in the renal cortex of preadolescents, respectively. Preadolescents with restricted diffusion had elevated urinary pro-inflammatory, chemotactic and pro-fibrotic cytokines, without elevations in blood markers of systemic inflammation, which was suggestive of renal inflammation.
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