Abstract #3805

Development of an MR Imaging Protocol for Ex-Vivo Assessment of Deceased Donor Human Kidneys

Alexander J Daniel¹, Sarah Fawaz², Philip Charles³, Mohamed Elzawahry², Jane I Grove⁴, David Long⁵, James Hunter², Maria Kaisar², and Susan T Francis¹

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom, ³Big Data Institute, Oxford University, Oxford, United Kingdom, ⁴NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom, ⁵Developmental Biology and Cancer Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom

Synopsis

Keywords: Kidney, Transplantation

Kidney transplantation is the preferred treatment for end-stage kidney disease. Donor kidney viability is currently assessed using donor age, medical history, and serum creatinine, but these have limited predictive power. As part of a study to determine if MRI can be used as an alternative, more accurate, measurement of donor kidney viability, we outline a multiparametric MRI protocol (high resolution structural scans, relaxometry (T₁, T₂ and T₂*) mapping, susceptibility-weighted-imaging (SWI), diffusion-weighted imaging (DWI), and magnetisation transfer ratio (MTR)) to study human whole kidneys that have been declined as transplants. MRI measures will be integrated with 3D-histology and tissue proteomics datasets.

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