Abstract #3810

Quantitative assessment of split renal function in early lupus nephritis using BOLD-MR: an initial study

Ye Wang^1,2, Zexuan Hu³, Chutong He^1,2, Ruili Wei^1,2, Xinrui Pang^1,2, Fangrong Liang^1,2, Aaron Zhang⁴, Yongzhou Xu⁴, Shiwen Yuan^1,5, and Ruimeng Yang^1,2

¹The second Affiliated Hospital Guangzhou, School of Medicine, South China University of Technology, Guangzhou, China, ²Department of Radiology, Guangzhou First People’s Hospital, Guangzhou, China, ³Department of Radiology, TCM-integrated Hospital of Southern Medical University, Guangzhou, China, ⁴Philips Healthcare, Guangzhou, China, Guangzhou, China, ⁵Department of Rheumatology, Guangzhou First People’s Hospital, Guangzhou, China

Synopsis

Keywords: Kidney, fMRI, split-renal functionLupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE) that can progress to end-stage kidney disease. This study aimed to detect the split-renal function changes in early-LN by using BOLD-MRI. The results demonstrated the R2*, as a biomarker for tissue oxygenation, was significantly lower in cortex and medulla in the early-LN patients compared to the healthy volunteers. Moreover, The R2* in medulla remained a considerable good power in predicting early-LN, suggesting it has the potential to be employed as a noninvasive imaging biomarker for early-LN patients with SLE.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.