Abstract #3811

Diffusion tensor imaging-based quantitative assessment of renal function in early-stage lupus nephritis

Chutong He^1,2, Ye Wang^1,2, Xinrui Pang^1,2, Ruili Wei^1,2, Fangrong Liang^1,2, Yongzhou Xu³, Aaron Zhang³, Shiwen Yuan^4,5, and Ruimeng Yang^1,2

¹The second Affiliated Hospital Guangzhou, School of Medicine, South China University of Technology, Guangzhou, China, ²Department of Radiology, Guangzhou First People’s Hospital, Guangzhou, China, ³Philips Healthcare, Guangzhou, China, ⁴Department of Rheumatology, The second Affiliated Hospital Guangzhou, School of Medicine, South China University of Technology, Guangzhou, China, ⁵Department of Rheumatology, Guangzhou First People’s Hospital, Guangzhou, China

Synopsis

Keywords: Kidney, Diffusion Tensor Imaging, Lupus nephritis

Lupus nephritis (LN) is a substantial cause of death in patients with systemic lupus erythematosus (SLE). The purpose of this study was to explore the value of Diffusion tensor imaging (DTI) in evaluating renal function in patients with early-stage LN. The results showed apparent diffusion coefficient (ADC) values in the cortex and fractional anisotropy (FA) values in the cortex and medulla were significantly lower in early-stage LN patients compared with healthy volunteers. Furthermore, FA values in the cortex and medulla were also independent predictors of early-stage LN, suggesting that FA values can be a potentially sensitive imaging biomarker.

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