Abstract #3813

Evaluation of renal allograft function using arterial spin labeling and blood oxygen level-dependent imaging

Jin Peng^1,2, Yajun Hong³, Feipeng Zhu⁴, Yanjun Li⁴, Song Luo⁵, Pu-Yeh Wu⁶, and Guangming Lu^1,5

¹The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China, ²Department of Interventional Therapy, Chenggong Hospital, Xiamen University, Xiamen, Fujian, China, ³Office of Medical Case Statistics, Department of Medical Affairs, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian, China, ⁴Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China, ⁵Department of Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China, ⁶GE Healthcare, Beijing, China

Synopsis

Keywords: Kidney, Quantitative Imaging, Arterial spin labelling, Blood oxygen level-dependent imaging, Renal allograftIn this study, we aimed to assess the renal allografts function after transplantation using ASL and BOLD MRI. We found that RBF and R2* values were significantly lower and higher in the renal transplant injury group, respectively. RBF and R2* were positively and negatively correlated with eGFR, respectively. ROC analysis demonstrated both RBF and R2* reflected injured renal function, and the combination of RBF and R2* showed an AUC of 0.86, comparable to that of RBF alone. In conclusion, compared to BOLD, ASL may be a more promising imaging technique for noninvasive assessment of renal graft function for clinical purposes.

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