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Abstract #3837

Exploration of age-related hemodynamic and mechanical changes in the human thoracic aorta using an atlas based approach

Elodie Piot1, Nicolas Duchateau1, Marine Menut2, Benyebka Bou-Said2, Patrick Clarysse1, Philippe Douek1,3, Karl Kunze4, Rene Botnar5, Sara Boccalini6, Claudia Prieto5, and Monica Sigovan1
1CREATIS, Lyon, France, 2INSA de Lyon, Lyon, France, 3Departement of Radiology, HCL, Lyon, France, 4Siemens Helthineers, London, United Kingdom, 5School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 6Department of Radiology, HCL, Lyon, France

Synopsis

Keywords: Data Processing, Blood vesselsUnderstanding the hemodynamic involvement in a vascular pathology requires inter-subject comparisons that are not straightforward due to variability in terms of aorta morphology. Hemodynamic atlases can facilitate detection of intra-group characteristics. We propose here a workflow to create a hemodynamic atlas using 4D Flow MRI. In addition, we propose to investigate the aorta wall stiffness using non-rigid image registration and inverse mechanical modeling. This type of analysis is expected to improve pathophysiological understanding of vascular disease, by enabling the investigation of potential correlations between hemodynamic and wall mechanical properties at each point of the aorta.

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