Abstract #3838

FMRI-based language mapping at 1.5 and 3T: the influence of methodological choices.

Khaliesah Bolhassan^1,2, Rachael Franklin³, Enrico De Vita⁴, Jozef Jarosz², and Marco Borri²

¹School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, ²Neuroradiology, King's College Hospital, London, United Kingdom, ³MRI Physics, Guy’s and St Thomas NHS Foundation Trust, London, United Kingdom, ⁴Radiology Department, Great Ormond Street Hospital for Children, London, United Kingdom

Synopsis

Keywords: fMRI (task based), Data Analysis

This work aims to assess the influence of methodological aspects in fMRI language mapping at 1.5T and 3T. Probability maps from healthy volunteer cohorts were compared to a published reference using a Dice Index vs probability threshold plot. T-value normalisation to the peak within the classic Broca/Wernicke’s language area as well as the inclusion of additional language tasks increased overlap to the reference. The extent of reproducible activation was larger at 3T.

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