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Abstract #3840

Investigation of cerebral blood flow and volume changes during positive and negative BOLD responses at 3T

Ratnamanjuri Devi1, Torsten Schlumm1, Toralf Mildner1, and Harald E Möller1
1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

Synopsis

Keywords: fMRI (task based), Arterial spin labelling, Vascular Space OccupancyCBF and CBV changes were measured sequentially, in regions of positive and negative BOLD responses, using a multi-echo center-out readout, known to reduce BOLD contaminations in pCASL and VASO measurements due to its short echo times. The CBV-CBF coupling was found to differ between positive and negative BOLD regions. The temporal relation of the CBF and VASO timecourses to their corresponding T2* timecourses, on the other hand, was found to be almost identical in the two ROIs.

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Keywords