Abstract #3844

Using PINS pulses to saturate inflow effects from slice gaps in functional MRI

Shota Hodono¹, Chia-yin Wu^1,2,3, Carl Dixon¹, Donald Maillet¹, Jin Jin⁴, Jonathan R Polimeni^5,6, and Martijn A Cloos¹

¹Centre for Advanced Imaging, The University of Queensland, St Lucia, Australia, ²ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, St. Lucia, Australia, ³chool of Information Technology and Electrical Engineering, The University of Queensland, St. Lucia, Australia, ⁴Siemens Healthcare Pty Ltd, Brisbane, Australia, ⁵Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁶Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: fMRI, Velocity & FlowIn this work, we demonstrate the use of PINS pulses to mitigate unwanted inflow effects in 2D multi-slice sequences. A PINS pulse was played prior to slice-selective excitation to saturate the magnetization within all slice gaps. Bloch simulation and flow-phantom experiments show inflow effects can be removed completely. Functional scans using twice-refocused spin echo suggest that inflow effects may have noticeable contributions to SE-BOLD fMRI response. This PINS implementation allows us to further understand fMRI signal dynamics by modulating the inflow effect.

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