Keywords: fMRI (resting state), Hypertension
Using a graph theory approach, functional connectivity differences in a 52 (32 hypertensive, 20 normotensive) subject cohort were tracked using resting-state fMRI. A null generation modification to a difference degree test (DDT) is profiled that resulted in increased true positivity rates in simulations while maintaining nominal false positivity rates. Applying the modified DDT to the hypertension cohort resulted in the discovery of 7 brain regions that exhibit significant groupwise differential expression along with 33 unique differentially expressed connections to other areas in the brain. The results presented agree with previous studies and represent a promising application of the modified DDT.
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