Abstract #3856

Changes in Aspartate Metabolism in the medial-prefrontal cortex of Nicotine Addicts Based on J-edited Magnetic resonance spectroscopy

Miaomiao Yu¹, Liangjie Lin², Ke Xu¹, Man Xu¹, Jianxin Ren¹, Xiaoyu Niu¹, Xinyu Gao¹, Mengzhe Zhang¹, Zhengui Yang¹, Jinghan Dang¹, Qiuying Tao¹, Shaoqiang Han¹, Weijian Wang¹, Jingliang Cheng¹, and yong zhang¹

¹Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²Clinical and Technical Support, Philips Healthcare, Beijing, China

Synopsis

Keywords: fMRI, Metabolism, Hydrogen proton magnetic resonance spectroscopy (1H MRS)Cigarette smoking harms nearly every organ of the body, causes many diseases, and reduces the health of smokers in general. Our study aims to explore the changes of aspartate (Asp) levels in the medial prefrontal cortex of patients with nicotine addiction using the J-edited 1H MRS technique. Results showed that the Asp level in medial prefrontal of nicotine addicts is relatively increased, suggesting that the metabolism of aspartate may play a key role in nicotine dependence.

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