Abstract #3860

**Neurochemical differences between 1p/19q codeleted and non-codeleted gliomas assessed by in vivo magnetic resonance spectroscopy**

Francesca Branzoli¹, Roberto Liserre², Dinesh Deelchand³, Pietro Luigi Poliani⁴, Franck Bielle⁵, Lucia Nichelli⁶, Marc Sanson^1,7, Stéphane Lehéricy^1,6,8, and Małgorzata Marjańska³

¹Sorbonne University, UMR S1127, INSERM U1127, CNRS UMR 7225, Paris Brain Institute - ICM, Paris, France, ²Department of Radiology, Neuroradiology Unit, ASST Spedali Civili University Hospital, Brescia, Italy, ³Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ⁴Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy, ⁵Laboratory R Escourolle, University Hospital La Pitié Salpêtrière, Paris, France, ⁶Department of neuroradiology, University Hospital La Pitié Salpêtrière, Paris, France, ⁷Department of neurology 2, University Hospital La Pitié Salpêtrière, Paris, France, ⁸Center for Neuroimaging Research (CENIR), ICM, Paris, France

Synopsis

Keywords: Spectroscopy, Cancer

Mutations in the genes encoding for isocitrate dehydrogenase (IDH), and 1p/19q codeletion are genetic alterations that can be often found in low-grade gliomas and are associated with better prognosis and response to treatment. Nevertheless, the biological effects of the 1p/19q codeletion are still not well known.

In this study, we compared the neurochemical profile of IDH-mutated, 1p/19q codeleted gliomas and their non-codeleted counterparts using in vivo magnetic resonance spectroscopy. We showed that the only metabolite that differed significantly between the two groups was cystathionine, pointing to this metabolite as the most useful biomarker for the identification of 1p/19q codeleted gliomas.

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