Abstract #3861

Correlation of NAAG level in the bilateral medial prefrontal cortex with nicotine dependence score in adult cigarette smokers

Liangjie Lin¹, Miaomiao Yu², Ke Xu², Man Xu², Jianxin Ren², Xiaoyu Niu², Xinyu Gao², Mengzhe Zhang², Zhengui Yang², Jinghan Dang², Qiuying Tao², Shaoqiang Han², Weijian Wang², Jingliang Cheng², and yong zhang²

¹Clinical and Technical Support, Philips Healthcare, Beijing, China, ²Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Synopsis

Keywords: Spectroscopy, Metabolism, Hydrogen proton magnetic resonance spectroscopy (1H MRS)Smoking can cause cancer, heart disease, stroke, lung diseases, diabetes, and chronic obstructive pulmonary disease including emphysema and chronic bronchitis. Our study aims to explore the correlation between neurotransmitter levels in the medial prefrontal cortex of patients with nicotine addiction (NA) using the J-edited 1H MRS technique. Results showed that the N-acetylaspartylglutamate (NAAG) level in medial prefrontal of nicotine addicts was significantly correlated with the score of Fagerstrom Test for Nicotine Dependence, suggesting that the metabolism of NAAG may play a key role in nicotine dependence patients.

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