Abstract #3862
Comparing 7 T FID-CRT-MRSI with 3 T MRF in High-Grade Gliomas
Philipp Lazen1, Sukrit Sharma2, Cornelius Cadrien1, Wolfgang Marik3, Thomas Roetzer-Pejrimovsky4, Eva Niess2, Lukas Hingerl2, Stephan Gruber2, Bernhard Strasser2, Barbara Kiesel1, Adelheid Wöhrer4, Matthias Preusser5, Julia Furtner3,6, Wolfgang Bogner2,7, Georg Widhalm1, Siegfried Trattnig2,7,8, Karl Rössler1,7, and Gilbert Hangel1,2,7
1Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, 2High-field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 3Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 4Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria, 5Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria, 6Medical Image Analysis and AI, Danube Private University, Krems, Austria, 7Christian Doppler Laboratory for MR Imaging Biomarkers, Vienna, Austria, 8Institute for Clinical Molecular MRI, Karl Landsteiner Society, St. Pölten, Austria
Synopsis
Keywords: Spectroscopy, Brain
We compared 7T MRSI-derived metabolic ratios with T1 and T2 maps from MR fingerprinting in a cohort of glioma patients by defining hotspots and calculating Dice similarity coefficients (DSCs) between them and a segmentation. Notable high DSCs were 0.799 for tCho/NAA vs T2 and 0.753 for Gln/NAA vs T1. We also investigated values for T1, T2, and metabolite ratios in tumors, hotspots, and a control region, with the median relaxation times being T1=1610 ms and T2=79 ms in the tumor, and T1=964 ms and T2=46 ms in NAWM.
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