Abstract #3863

Altered cortical metabolism contributes to cognitive deficits in a healthy military cohort

Julie M Joyce^1,2, Kristin Heaton³, Huijun J Liao², and Alexander P Lin²

¹cBRAIN, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany, ²Center for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, ³Military Performance Division, United States Army Research Institute of Environmental Medicine, Natick, MA, United States

Synopsis

Keywords: Spectroscopy, Neuro, MilitaryThe selection of control groups is of increasing interest in military research. Here, we used single voxel magnetic resonance spectroscopy (MRS) to probe cortical metabolism in the anterior and posterior cingulate gyri, temporal lobe and parietal white matter in healthy military service members and civilian controls. Computerized neuropsychological tests were administered to evaluate neurocognitive abilities. We identified higher incidence of cognitive deficits in military service members relative to civilian controls as well as associations between neurometabolite levels and poor cognitive performance.

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