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Abstract #3872

Direct comparison of deuterium 2H MRSI at 3T vs 7T

Jabrane Karkouri *1, Mary McLean *2, Minghao Zhang *1, Joshua D Kaggie2, Ashley Grimmer2, Alixander Khan2, Tomasz Matys2, Daniel Atkinson1, Ferdia Gallagher *2, and Christopher Rodgers *1
1University of Cambridge, Cambridge, United Kingdom, 2Radiology, University of Cambridge, Cambridge, United Kingdom

Synopsis

Keywords: Deuterium, DeuteriumDeuterium metabolic imaging (DMI) is a new method to probe brain metabolism. Theory predicts higher SNR at higher field strength, but clinical translation is easier at lower field strength. We undertook 2H MRSI in 3 healthy volunteers at 3T and 7T sequentially. Acquisition was undertaken at baseline and after 11.1g oral D2O consumption. Data quality was acceptable in all scans. SNR was 3x higher at 7T, in agreement with theory. D2O cerebral uptake rate was similar between field strengths (0.13 min-1 at 3T vs 0.07 min-1 at 7T).

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Keywords