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Abstract #3873

Deuterium oxide MRI to image the water inflow in the bovine lens of the eye

Xingzheng Pan1, Emily MacFarlane1, and Paul Donaldson1
1Physiology, University of Auckland, Auckland, New Zealand

Synopsis

Keywords: Deuterium, Aging, Human eyeIn the absence of a blood supply the lens operates an internal microcirculation to deliver nutrients, remove metabolic wastes, and controll the lens volume, which together to maintain the optical properties of the lens. While this microcirculation is generated by circulating fluxes of ions and water, visualising water flow throughout the whole lens and especially into the central of lens in real time has proven challenging. To address this, we developed and optimised new deuterium oxide (D2O) MRI protocols to image water flow within multiple organ-cultured bovine lenses that can be routinely performed using 3T clinical MRI.

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