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Abstract #3875

Estimating Uncertainty of Deep Learning for Tomographic Image Reconstruction Through Local Lipschitz

Danyal Bhutto1,2, Bo Zhu2, Jeremiah Zhe Liu3,4, Neha Koonjoo2,5, Bruce R Rosen2,5, and Matthew S Rosen2,5,6
1Biomedical Engineering, Boston University, Boston, MA, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 3Google, Mountain View, CA, United States, 4Biostatistics, Harvard University, Cambridge, MA, United States, 5Harvard Medical School, Boston, MA, United States, 6Physics, Harvard University, Boston, MA, United States

Synopsis

Keywords: Machine Learning/Artificial Intelligence, Image ReconstructionAs deep learning approaches for image reconstruction become increasingly used in the radiological space, strategies to estimate reconstruction uncertainties become critically important to ensure images remain diagnostic. We estimate reconstruction uncertainty through calculation of the Local Lipschitz value, demonstrate a monotonic relationship between the Local Lipschitz and Mean Absolute Error, and show how a threshold can determine whether the deep learning technique was accurate or if an alternative technique should be employed. We also show how our technique can be used to identify out-of-distribution test images and outperforms baseline metrics, i.e. deep ensemble and Monte-Carlo dropout.

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