Abstract #3916

Identifying spreading depression during coma induction with multi-modal fMRI

Yuanyuan Jiang¹, Zeping Xie¹, Wenchao Yang¹, Bei Zhang¹, David Hike¹, Andy Liu^1,2, Brian L. Edlow^1,3, and Xin Yu¹

¹Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Neuroscience, Boston University, Boston, MA, United States, ³Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, United States

Synopsis

Keywords: Stroke, Ischemia, coma, spreading depressionWe have demonstrated spreading depression as a key event contributing to coma induction following the ET-1 injection to the brainstem of rats. Multi-modal fMRI enables the whole brain functional mapping to present the spatial dynamic changes during coma induction, in particular, paired with the incidence of SD events.

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