Keywords: Molecular Imaging, Drug DevelopmentThe goal of this study was to detect the changes of cerebral blood volume (CBV) in the non-human primate brain induced by administration of agonist and antagonist of cannabinoid receptor 1 (CB1R) using simultaneous positron emission tomography (PET) and function magnetic resonance imaging (fMRI). After the antagonist injection, a bi-phasic response, fast increase and prolonged decrease of CBV, were identified throughout the brain, while CB1R agonist administration evoked elevation of CBV. Future studies integrating PET-derived receptor occupancy information with the CBV changes will provide deeper understanding on CB1R and brain response.
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