Abstract #3920

Development and application of dynamic MRSI of an HP neuroprotective agent in an MCAO mouse model of ischemic stroke at 14.1 T

Thanh Phong Lê^1,2, Lara Buscemi³, Mario Lepore⁴, Andrea Capozzi^1,5, Lorenz Hirt³, Mor Mishkovsky¹, and Jean-Noël Hyacinthe^2,6

¹Laboratory of Functional and Metabolic Imaging, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, ²Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Geneva, Switzerland, ³Department of Clinical Neurosciences, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ⁴CIBM Center for Biomedical Imaging, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁵Department of Health Technology, Center for Hyperpolarization in Magnetic Resonance, Technical University of Denmark, Kgs Lyngby, Denmark, ⁶Image Guided Intervention Laboratory, University of Geneva (UNIGE), Geneva, Switzerland

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Preclinical, Molecular Imaging

Advanced acquisition hardware and sequences boosting the spatiotemporal resolution overcome the existing limitations of HP metabolic MRI in animal disease models, providing new contrasts and opening up new perspectives. Herein, we designed a ¹H/¹³C volume/surface-combined head coil providing full mouse brain coverage with high sensitivity, as well as a high-efficiency acquisition scheme to achieve superior spatial and temporal resolution images. This setup was employed for time-resolved imaging of the cerebral metabolic response to a neuroprotective bolus of hyperpolarized pyruvate in a transient hypoxia/ischemia mouse model. The experiments suggest a distinct metabolism between the ischemic and healthy tissues.

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