Abstract #3924

Metabolic Activity Diffusion Imaging [MADI] of Rat Brain Glioma

Joshua Schlegel¹, Eric Baker¹, Samantha Holland², Jared Stoller³, William Packwood⁴, Xin Li¹, Ramon Barajas³, Charles Springer¹, and Martin Pike¹

¹AIRC, OHSU, Portland, OR, United States, ²Neurology, OHSU, Portland, OR, United States, ³Diagnostic Radiology, OHSU, Portland, OR, United States, ⁴Research Cores and Shared Resources, OHSU, Portland, OR, United States

Synopsis

Keywords: Molecular Imaging, Metabolism, Cancer

We compared the novel DWI MRI-based metabolic activity [MA] imaging approach [MADI] to ¹⁸FDG-PET, employing an in vivo rat glioma model. The MADI-derived parameter, k_io*V product, is proportional to Na⁺/K⁺ ATPase [NKA] activity, the primary cellular energy consumer. The k_ioV decreased within the tumor vs. contralateral while ¹⁸FDG uptake increased. This is consistent with the Warburg effect in glioma, which activates glucose uptake but also switches energy production from mitochondrial oxidative phosphorylation to glycolysis, thus reducing overall ATP production and NKA activity. MADI expands DWI MRI utility, providing a novel, noninvasive MA imaging method, with greater resolution than PET.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.