Keywords: Spectroscopy, Diffusion/other diffusion imaging techniques, brain, preclinical, sequence design
Brain glutamine (Gln) is a key biomarker of hepatic encephalopathy (HE). The estimation of its diffusion properties with diffusion-weighted MRS is of high interest in the field but remains challenging due to its low concentration. We propose a new diffusion-weighted MRS sequence, DW-SPECIAL, which enables to reach shorter echo times and is thus beneficial for strongly J-coupled metabolites such as Gln. DW-SPECIAL reduces the uncertainty in Gln diffusion decays and the standard deviation across animals for Gln diffusivity in a homogenous control population and paves the way for an in-depth study of Gln diffusion properties in HE.
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