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Abstract #3927

9 crossings per 1 bend: Tractography of contra- and ipsilateral connections in mouse optic pathways improved with ODF-Fingerprinting

Patryk Filipiak1, Thajunnisa A. Sajitha2, Timothy Shepherd1, Kamri Clarke1, Dimitris G. Placantonakis3, Jiangyang Zhang1, Kevin C. Chan2, Fernando E. Boada4, and Steven H. Baete1
1Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, NYU Langone Health, New York, NY, United States, 2NeuroImaging and Visual Science Laboratory, Departments of Ophthalmology and Radiology, NYU Langone Health, New York, NY, United States, 3Department of Neurosurgery, Perlmutter Cancer Center, Neuroscience Institute, Kimmel Center for Stem Cell Biology, NYU Langone Health, New York, NY, United States, 4Radiological Sciences Laboratory and Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, Stanford, CA, United States

Synopsis

Keywords: Image Reconstruction, White Matter, tractography, optic pathways, optic tract, optic chiasm, crossing fibersReconstruction of rodent optic pathways is particularly challenging for dMRI tractography due to the relatively small size of the crossing area in the optic chiasm and the unbalanced proportion between the contra- and ipsilateral axonal links. In this study, we replace the commonly used Orientation Distribution Function peak finding approach with our dictionary-based technique called ODF-Fingerprinting to improve the reconstruction of crossing fibers and thus correct the proportion of tracts exiting the optic chiasm. Our results from in vivo diffusion-weighted images of 18 mice show significant improvement (p<0.05) in many cases, helping decrease the discrepancies between reconstruction and gold-standard histology.

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