Keywords: Image Reconstruction, White Matter, tractography, optic pathways, optic tract, optic chiasm, crossing fibersReconstruction of rodent optic pathways is particularly challenging for dMRI tractography due to the relatively small size of the crossing area in the optic chiasm and the unbalanced proportion between the contra- and ipsilateral axonal links. In this study, we replace the commonly used Orientation Distribution Function peak finding approach with our dictionary-based technique called ODF-Fingerprinting to improve the reconstruction of crossing fibers and thus correct the proportion of tracts exiting the optic chiasm. Our results from in vivo diffusion-weighted images of 18 mice show significant improvement (p<0.05) in many cases, helping decrease the discrepancies between reconstruction and gold-standard histology.
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