Abstract #3928

Imaging the transmembrane pH gradient in gliomas

Sandeep Kumar Mishra¹, Jelena Mihailović¹, Fahmeed Hyder^1,2, and Daniel Coman¹

¹Radiology & Biomedical Imaging, Yale University, New Haven, CT, United States, ²Biomedical Engineering, Yale University, New Haven, CT, United States

Synopsis

Keywords: Molecular Imaging, Cancer, transmembrane pH

Extracellular acidosis in relation to intracellular milieu is a unique feature of the tumor microenvironment. The difference between intracellular pH (pH_i) and extracellular pH (pH_e) is much larger in tumors than normal tissue. Measuring the transmembrane pH gradient (ΔpH=pH_i–pH_e) could provide a tool for assessing tumor aggressiveness, monitoring treatment efficacy, guiding localized drug delivery, and understanding tumor responsiveness. This work establishes transmembrane pH gradient imaging in brain tumors. We observed a significantly higher transmembrane pH gradient in RG2 tumors compared to normal brain. Decreasing transmembrane pH gradient may serve as a functional biomarker for positive therapeutic outcome.

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