Abstract #3929

Mapping the effect of oxytocin on the mouse brain using Q2TIPS arterial spin labelling and BOLD fMRI at 9.4T

Eugene Kim¹, Davide di Censo¹, Zhuoni Li², Eilidh MacNicol¹, Alexandra Hertz², Michael Craig², Diana Cash¹, and Marija M Petrinovic²

¹Department of Neuroimaging, King's College London, London, United Kingdom, ²Department of Forensic and Neurodevelopmental Sciences, King's College London, London, United Kingdom

Synopsis

Keywords: Brain Connectivity, Arterial spin labelling, pharmacological MRI

Currently, standard Bruker protocols for arterial spin labelling (ASL) in mice are limited to single-slice methods. Here, we implemented multi-slice Q2TIPS ASL on a Bruker 9.4T scanner for whole-brain mapping of cerebral blood flow (CBF) in mice. There was good agreement between Q2TIPS and the standard Bruker FAIR ASL. Pharmacological MRI using Q2TIPS ASL and BOLD fMRI revealed that systemic administration of a behaviorally relevant dose of oxytocin caused a global decrease in CBF and increase in functional connectivity in healthy, wildtype mice. These opposing effects corroborate a recent concept of mutual exclusivity between neuronal activity and functional connectivity.

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