Abstract #3930

A water-exchange dynamic contrast-enhanced MRI protocol optimized for AQP4 measurement in glioma

Guangxu Han¹, Yinhang Jia¹, Zejun Wang¹, Yi-Cheng Hsu², and Ruiliang Bai^3,4

¹Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ²MR Collaboration, Siemens Healthcare, Shanghai, China, ³Zhejiang University School of Medicine, Hangzhou, China, ⁴College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China

Synopsis

Keywords: Contrast Agent, Tumor

A dynamic contrast-enhanced MRI (DCE-MRI) protocol was optimized to measure transmembrane water exchange rate (k_io), which was correlated k_io with aquaporin-4 (AQP4) immunohistochemistry results in a rodent subcutaneous glioma model. From the acquired results, a significant correlation was demonstrated between the optimized k_io and AQP4, indicating that k_io measured by DCE-MRI could reveal the expression of AQP4.

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