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Abstract #3934

Rejecting or retaining motion corrupted transients in diffusion-weighted MRS: high b-values and multiple directions

Clémence Ligneul1, Jesper Andersson1, Saad Jbabdi1, Jason Lerch1,2,3, and William T Clarke1
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada, 3Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Data Processing, Spectroscopy, Diffusion-weighted spectroscopyRobust processing is crucial for a reliable microstructural interpretation of advanced diffusion-weighted magnetic resonance spectroscopy (DW-MRS) methods. The spectral signal intensity depends on the direction when using strong diffusion-gradients and multiple directions, even more if the voxel content is very anisotropic (e.g. contains a white matter tract). In this study we propose a model-based way of identifying motion corrupted averages that accounts for the voxel anisotropy.

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Keywords