Abstract #3934

Rejecting or retaining motion corrupted transients in diffusion-weighted MRS: high b-values and multiple directions

Clémence Ligneul¹, Jesper Andersson¹, Saad Jbabdi¹, Jason Lerch^1,2,3, and William T Clarke¹

¹Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ²Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada, ³Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Data Processing, Spectroscopy, Diffusion-weighted spectroscopyRobust processing is crucial for a reliable microstructural interpretation of advanced diffusion-weighted magnetic resonance spectroscopy (DW-MRS) methods. The spectral signal intensity depends on the direction when using strong diffusion-gradients and multiple directions, even more if the voxel content is very anisotropic (e.g. contains a white matter tract). In this study we propose a model-based way of identifying motion corrupted averages that accounts for the voxel anisotropy.

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