Abstract #3936

Simultaneous in vivo Detection of Cystathionine and 2HG at 7T and Simulation of MEGA and SLOW-editing performance

Guodong Weng^1,2, Piotr Radojewski^1,2, and Johannes Slotboom^1,2

¹Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland, ²Translational Imaging Center, sitem-insel, Bern, Switzerland

Synopsis

Keywords: Pulse Sequence Design, Spectroscopy, Spectral editing

2-Hydroxyglutarate (2HG) is a biomarker for IDH-mutant glioma, and previous studies have shown that cystathionine (Cys) can be a potential biomarker for 1q/19q co-deletion of glioma. Previous studies used SVS based MEGA-editing MRS to detect 2HG and co-edited Cys, but editing efficiency of Cys is not optimal due to the narrow bandwidth of the applied MEGA editing-pulses. This work shows that SLOW-editing is able to detect both 2HG and Cys in an optimal way with whole-brain coverage.

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