Abstract #3938

Development of a 2D MRSI sequence with Chemical-Shift Selective Adiabatic Pulses (2𝜋-CSAP) using Pulseq at 7T

Kyung Min Nam^1,2,3, Guodong Weng^2,3, Nam G Lee⁴, Edwin Versteeg¹, Yeong-Jae Jeon^5,6, Arjan Hendriks¹, Jannie Wijnen¹, Alex Bhogal¹, Dennis Klomp¹, Maxim Zaitsev⁷, and Johannes Slotboom^2,3

¹Department of High Field MR, Centre for Image Sciences, University of Medical Centre Utrecht, Utrecht, Netherlands, ²Institute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland, ³Translational Imaging Center, sitem-insel AG, Bern, Switzerland, ⁴Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ⁵Lee Gil Ya Cancer & Diabetes Institute, Gachon University, Incheon, Korea, Republic of, ⁶Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, Korea, Republic of, ⁷Department of Radiology, Division of Medical Physics, University Medical Center Freiburg, Freiburg, Germany

Synopsis

Keywords: Data Acquisition, SpectroscopyAn MRSI sequence using a pair of chemically selective adiabatic 2𝜋 refocus pulses, referred to as 2𝜋-CSAP, was implemented using the open-source Pulseq framework. This sequence enables full coverage of the frequency spectrum of interest through a shift in carrier frequency, which has been a limitation in rapid MRSI sequences. In addition, this shifted frequency spectrum also minimizes signal contaminations from residual water signal after water suppression or unsuppressed water signal and strong lipid signals, possibly eliminating the need for additional water suppression pre-pulses. This base sequence can potentially be combined with accelerated acquisition techniques for better scan efficiency.

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