Abstract #3948

Alterations in cerebral metabolism from wakefulness to non-REM sleep

Jing Xu¹, Michael C Langham¹, Hengyi Rao², Marianne Nabbout¹, Alessandra S Caporale^1,3,4, Alexander M Barclay¹, John A Detre², and Felix W Wehrli¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Neurosciences, ‘G. d’Annunzio University’ of Chieti-Pescara, Chieti, Italy, ⁴Institute for Advanced Biomedical Technologies (ITAB), ‘G. d’Annunzio University’ of Chieti-Pescara, Chieti, Italy

Synopsis

Keywords: Data Analysis, MetabolismSleep is fundamental to human health and function. Cerebral metabolism and blood supply are key physiological parameters of brain function, but the manner in which they change during different sleep stages is still largely unknown. In this study, we collected wakefulness and sleep data with concurrent EEG-MRI. We measured CBF, SvO₂ and CMRO₂ with radial OxFlow MRI. Our data show that CMRO₂ is lower during non-REM sleep than during wakefulness and declines progressively as sleep stages become deeper. CBF decreases during non-REM sleep compared with wakefulness, while SvO₂ gradually increases from wakefulness to slow wave sleep.

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