Abstract #3950

Long-term balance training enhances sensorimotor GABA levels in older adults: A 7 T longitudinal magnetic resonance spectroscopy study

Xinyu Liu^1,2,3, Selin Scherrer⁴, Sven Egger⁴, Song-I Lim^1,3, Benedikt Lauber⁴, Wolfgang Taube⁴, and Lijing Xin^1,3

¹Animal Imaging and Technology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Laboratory for functional and metabolic imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ³Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, ⁴Department of Neurosciences and Movement Science, University of Fribourg, Fribourg, Switzerland

Synopsis

Keywords: Data Acquisition, Spectroscopy, Data analysis, motor training, GABA, 7 Tesla

This study aims to examine the modulatory effect of long-term balance training on sensorimotor cortex GABA level in an older population. In-vivo GABA levels were accessed using in-vivo MR spectroscopy (MRS) at 7T. GABA level in sensorimotor cortex was measured in sixteen healthy older adults using MEGA-sSPECIAL sequence, and short echo time semi-sSPECIAL sequence was used for metabolite profiling, before and after a three-months period of balance training. Using edited MEGA-sSPECIAL we detected a significant increase in sensorimotor GABA level after training, indicating potentially enhanced motor inhibition by coordinative balance learning.

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