Abstract #3952

GABA spectroscopic imaging at 9.4T to localize the epileptogenic zone in an animal model of focal epilepsy

Alicia Plaindoux¹, Yann Le Fur², Jia Guo³, Clothilde Courivaud¹, Julien Valette⁴, Vasile Stupar^1,5, and Florence Fauvelle^1,5

¹Grenoble Institute Neurosciences, INSERM, U1216, University Grenoble Alpes, Grenoble, France, ²CRMBM, Aix-Marseille University, Marseille, France, ³Departement of Psychiatry, Columbia University, New York, NY, United States, ⁴Université Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France, ⁵IRMaGe, INSERM, US17, CNRS, UMS 3552, CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France

Synopsis

Keywords: Data Acquisition, Spectroscopy, MEGA-LASER, CSI, edition

A surgical resection of the epileptogenic zone (EZ) can be proposed to drug-resistant epileptic patients, mainly suffering from focal epilepsy, in order to free them from their seizures. However, the mean efficiency of surgery is around 50 to 80%, indicating a possible miss-delimitation of the EZ. In recent studies, GABA was found to be a specific biomarker of the EZ in a mouse model of mesio-temporal lobe epilepsy (MTLE). Therefore, in this project, we propose a GABA-edited spectroscopic imaging method to improve the spatial localization of the EZ in this mouse model.

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