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Abstract #3961

In Vivo Diffusion MRI at 7 T: High Spatial-Angular-Temporal Resolution Pursuit

Frank Z Tan1, Patrick Alexander Liebig2, Robin Martin Heidemann2, Frederik Bernd Laun3, and Florian Knoll1
1Artificial Intelligence in Biomedical Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 2Siemens Healthcare GmbH, Erlangen, Germany, 3Institute of Radiology, University Hospital Erlangen, Erlangen, Germany

Synopsis

Keywords: Image Reconstruction, Diffusion/other diffusion imaging techniques, Ultra high field, multi-shell, q-space, crossing fiberThe pursuit of high-spatial-angular-temporal resolution for in vivo diffusion MRI at 7T is challenging, but also receives continuous interest. We hereby propose shift-encoded interleaved EPI and a joint reconstruction technique with LLR regularization. Preliminary results achieve up to 8.7-fold acceleration per shot in 2-shot EPI acquisition with 1.4 mm isotropic nominal resolution. Moreover, with the integrated joint reconstruction for noise reduction, high-quality diffusion-weighted images render more spatially-continuous fiber anisotropy maps and clearer fiber crossing in the fiber orientation distribution function.

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Keywords