Keywords: Software Tools, Diffusion/other diffusion imaging techniques, Tractography, tractometry, bundle segmentation, white matter tracts, group analysisWe propose BUAN 2.0, which adds new advancements to its predecessor BUAN. It sub-segments bundles with varying substructures in them. It uses nonlinear registration of bundles to find accurate correspondences among bundle segments across subjects. The number of horizontal segments is decided based on the bundle and data specifications. More importantly, in BUAN 2.0, instead of treating each point on the streamline as an independent observation, we treat each streamline as a complete entity, as a function. Streamlines are analyzed by deploying functional data analysis (FDA) methods for studying group differences in populations along the length of the tracts.
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