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Abstract #3971

The Trouble with Free-Water Elimination using Single-Shell Diffusion MRI Data: A Case-Study in Ageing

Marta M. Correia1, Stefan Winzeck2,3, Marc Golub4, and Rita G. Nunes4
1MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom, 2BioMedIA Group, Department of Computing, Imperial College London, London, United Kingdom, 3Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 4Institute for Systems and Robotics - Lisboa and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal

Synopsis

Keywords: Data Analysis, Diffusion/other diffusion imaging techniques, Ageing, Free-Water

Two different algorithms for free-water elimination (FWE) were applied to single-shell and multi-shell diffusion MRI data. Positive correlations were found between age and fractional anisotropy (FA) estimated with the FWE algorithm for single-shell, but this was not replicated with multi-shell diffusion data. Because only the multi-shell FWE algorithm is well-posed, we postulated that the positive correlations between age and FA must be a false positive finding, resulting from inappropriate fitting using single-shell data. FWE estimates from single-shell modelling have been shown to be biologically plausible, but this does not imply specificity, and more work is required to validate these approaches.

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Keywords