Abstract #3974

Abnormal functional connectivity of the hippocampus and amygdala in plateau Tibetan with type 2 diabetes mellitus

Jinli Meng^1,2,3, Yingxue Gao², Hailong Li², Lingxiao Cao², Wanlin He¹, Li Feng¹, Yongyue Guo¹, Xin Hu¹, Hengyan Li¹, Chenghui Zhang⁴, Yunhong Wu⁴, and Xiaoqi Huang^2,3

¹Department of Radiology, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region (Hospital. C.T.), Chengdu, Sichuan, China, ²Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China, ³Psychoradiology Research Unit of the Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Chengdu, Sichuan, China, ⁴Department of Endocrinology and Metabolism, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region (Hospital. C.T.), Chengdu, Sichuan, China

Synopsis

Keywords: Endocrine, DiabetesWe performed a seed-based rsFC study to explore the hippocampus and the amygdala FC patterns in plateau Tibetan patients with T2DM. We found that, compared to plateau Tibetan HC, T2DM showed both increased rsFC between the right hippocampus and left DLPFC and left SFG, and between the left amygdala and right OFC as well as right DLPFC.Moreover, these rsFC abnormalities were significantly correlated with age, RBC and changes of visuospatial memory function in plateau Tibetan patients with T2DM. These findings of altered FC may provide important insights into the neural basis of diabetes-related cognitive decline in plateau Tibetan.

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