Abstract #3980

Impact of genotype on pancreatic iron overload and impaired glucose metabolism in thalassemia major.

Antonella Meloni¹, Laura Pistoia¹, Vincenzo Positano¹, Nicolò Schicchi², Gennaro Restaino³, Luigi Barbuto⁴, Ada Riva⁵, Giuseppe Peritore⁶, Letizia Tedesco⁷, Angela Ermini⁸, Domenico Visceglie⁹, Costanza Bosi¹⁰, Paola Maria Grazia Sanna¹¹, and Filippo Cademartiri¹

¹Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, ²Azienda Ospedaliero-Universitaria Ospedali Riuniti "Umberto I-Lancisi-Salesi", Ancona, Italy, ³Gemelli Molise SpA, Fondazione di Ricerca e Cura "Giovanni Paolo II", Campobasso, Italy, ⁴Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli, Napoli, Italy, ⁵Ospedale “SS. Annunziata” ASL Taranto, Taranto, Italy, ⁶"ARNAS" Civico, Di Cristina Benfratelli, Palermo, Italy, ⁷Presidio Ospedaliero Locri - A.S.P di Reggio Calabria, Locri (RC), Italy, ⁸Ospedale S. Maria Annunziata, Bagno a Ripoli (FI), Italy, ⁹Ospedale “Di Venere”, Bari, Italy, ¹⁰Ospedale “G. Da Saliceto”, Piacenza, Italy, ¹¹Azienda Ospedaliero-Universitaria di Sassari, Sassari, Italy

Synopsis

Keywords: Pancreas, Tissue CharacterizationOn the basis of the type of gene mutation, three groups of patients with thalassemia major were identified: homozygotes β+, compound heterozygotes β+/β° and homozygotes β°. β0β0 patients were more likely to have pancreatic iron overload than both β+β+ patients and β0β+patients and had a double risk of alterations of glucose metabolism compared to β+β+ patients. Our findings support the knowledge of the different genotypic groups in the clinical management of β-TM patients.

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