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Abstract #3984

MR Elastography of the affected mesenteric fat in active Crohn’s Disease: a feasibility study

Anne-Sophie van Schelt1,2, Kim Johanna Beek1,3, Nienke Petronella Maria Wassenaar1, Eric M. Schrauben1, Jurgen H. Runge1, Aart J. Nederveen1, and Jaap Stoker1,2,3
1Radiology and Nuclear Medicine, AmsterdamUMC, location AMC, Amsterdam, Netherlands, 2Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands, 3Endocrinology, Metabolism, Amsterdam Gastroenterology, Amsterdam, Netherlands

Synopsis

Keywords: Digestive, Quantitative ImagingCrohn’s Disease (CD) is a chronic inflammatory bowel disease. Mesentery of afflicted bowel loops often is involved. MR-Elastography allows assessment of its underlying mechanical properties and gives more insight in the role of the mesentery . Feasibility was first shown in 15 healthy volunteers. Seven patients with active CD (aCD) scheduled for surgical intervention underwent pre-operative MR-Elastography acquisition and histopathological analysis. Seven age- and sex matched volunteers were also scanned. Significantly higher shear wave speed, shear stiffness and phase angle were found in aCD patients, possibly related to increased fibrotic tissue in or inflammation of the mesentery.

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