Abstract #3996

Rapid Myocardial T1 Stress/Rest Reactivity Mapping in Ferumoxytol-enhanced Cardiac MRI: Initial Results

Hazar Benan Unal¹, Shahriar Zeynali¹, Fei Han², Gregory J. Anthony³, Subha Raman⁴, Balaji Tamarappoo⁵, Rohan Dharmakumar¹, and Behzad Sharif¹

¹Krannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, IN, United States, ²Siemens Medical Solutions, Inc., Los Angeles, CA, United States, ³Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, United States, ⁴Cardiovascular Medicine, IU Health/IU School of Medicine, Indianapolis, IN, United States, ⁵Indiana University Health, Indianapolis, IN, United States

Synopsis

Keywords: Myocardium, Ischemia, dobutamineMyocardial T1 reactivity, defined as the relative T1 change from rest to stress, has been proposed as a marker for detection of ischemic heart disease. SASHA-based T1 mapping provides higher accuracy than MOLLI, but the scan time can be prohibitive under stress. In this work, we investigated the feasibility of accelerated SASHA T1 mapping for ferumoxytol-enhanced dobutamine-stress T1 reactivity studies at 3T in a preclinical setting. We showed that a 2-fold accelerated SASHA T1 mapping can provide sufficiently accurate results compared to conventional SASHA.

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