Abstract #4000

Using Quantitative MR and Histology to Characterize Acute and Chronic DVT at 9.4T

Caroline D. Jordan^1,2, Kavya Sinha², Deborah C. Vela³, L. Maximillian Buja^3,4, Christof Karmonik^2,5, and Trisha L. Roy^2,5

¹School of Engineering Medicine, Texas A&M University, Houston, TX, United States, ²Houston Methodist Research Institute, Houston Methodist Hopsital, Houston, TX, United States, ³Department of Cardiovascular Pathology, Texas Heart Institute, Houston, TX, United States, ⁴Department of Pathology and Laboratory Medicine, University of Texas, Houston, Houston, TX, United States, ⁵Weill Cornell Medical College, Houston, TX, United States

Synopsis

Keywords: Vessels, Tissue Characterization, DVT, clotDeep venous thrombosis (DVT) is common. Mechanical thrombectomy may offer advantages compared to medical therapy alone, but it can be challenging to determine the optimal treatment. Six patients underwent thrombectomy, and the ex vivo clot was scanned at 9.4T. We acquired T₁, T₂, and T₂* maps, and histologic content of red blood cells, fibrin, and collagen. R² between RBC content and each relaxation time was R² = 0.58 for T₁, R² = 0.82 for T₂, and R² = 0.69 for T₂*. T₁, T₂, and T₂* mapping of ex vivo DVT clots at 9.4T may be feasible for determining clot components.

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