Abstract #4011

T1 mapping and extracellular volume for evaluating myocardial fibrosis in animal models with ischemia with non-obstructive coronary artery

Zilong Ren¹, Didi Wen², Jianxiu Lian³, Jiantao Liu³, Zhe Huang³, and Minwen Zheng⁴

¹Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China, ²Department of Radiology, Xijing Hospital, Forth Military Medical University, Xi'an, China, ³Philips Healthcare China, Xi'an, China, ⁴Xijing Hospital, Fourth Military Medical University, Xi'an, China

Synopsis

Keywords: Cardiomyopathy, AnimalsTo investigate whether T1 mapping and extracellular volume (ECV) can be used as predictors of myocardial fibrosis for ischemia with non-obstructive coronary artery disease (INOCA). Results showed pigs models with INOCA had higher native T1 mapping and ECV (mean native T1 mappingnormal = 1068.3 ± 111.5 ms, mean native T1 mappingINOCA = 1291.7 ± 109.2 ms, P = 0.018; mean ECVnormal = 23.0 ± 1.7 %, mean ECVINOCA = 46.6 ± 10.4 5, P = 0.006). T1 mapping technology could be a noninvasive way for assessing the myocardial fibrosis for INOCA models.

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