Abstract #4017

Venous blood oxygenation measurements using TRUST and T2-TRIR during hypoxic and hypercapnic gas challenges

Koen P.A. Baas¹, Chau Vu², Jian Shen², Bram F. Coolen³, Gustav J. Strijkers³, John C. Wood^2,4, and Aart J. Nederveen¹

¹Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, ²Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ³Biomedical Engineering and Physics, Amsterdam UMC, Amsterdam, Netherlands, ⁴Division of Cardiology, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: Oxygenation, OxygenationTRUST and T2-TRIR can be used to measure venous blood oxygenation (Y_v) and oxygen extraction fraction (OEF). T2-TRIR also offers simultaneous blood T1 (T1_b) measurements for hematocrit calculation in lieu of invasive blood samples. Here, TRUST and T2-TRIR were compared across a broad Y_v range using hypoxic and hypercapnic challenges in healthy volunteers, while T2-TRIR-derived hematocrit estimates were compared with venipuncture results. T2-TRIR- and TRUST-derived Y_v and OEF values exhibited a small constant bias (-5.4±3.5% and 6.0±4.0% respectively, both p<0.01) across all stimuli. Hematocrit by venipuncture and from T1_b were unbiased but had broad confidence intervals (1.7±6.3%, p=0.20).

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