Abstract #4018

Study of Oxidative Stress due to X-ray Irradiation in Mouse Brain using TOLD MRI Imaging

Raj Kumar Parajuli¹, Megumi Ueno², Saaya Suzuki¹, Akira Sumiyoshi¹, Takayuki Obata¹, Ichio Aoki¹, and Ken-ichiro Matsumoto²

¹Department of Molecular Imaging and Theranostics, National Institutes for Quantum Science and Technology (QST), Chiba, Japan, ²Department of Radiation Regulatory Science Research, National Institutes for Quantum Science and Technology (QST), Chiba, Japan

Synopsis

Keywords: Oxygenation, Brain, Oxidative stress, TOLD, X-ray irradiationThis study aims to evaluate the metabolic changes caused on the brain tissues due to radiation exposure to healthy tissues while tumor treatment. The tissue oxidization and reduction mechanism represented by redox imaging could be a suitable index to evaluate in vivo oxidative stress in living animals that could evaluate metabolic damages due to irradiation. We adopted tissue oxygen level dependent (TOLD) MRI imaging to analyze TOLD signal for the control group mice and the irradiated mice. The result shows the distinct oxygen consumption levels in the control and the irradiated mice.

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