Abstract #4020

Zero-echo time (ZTE) pulse sequence enables EEG-fMRI with suppression of susceptibility artifacts.

Ayako Imamura^1,2,3, Rikita Araki⁴, Yukari Takahashi³, Koichi Miyatake², Fusao Kato³, Sakiko Honjoh², and Tomokazu Tsurugizawa^3,5,6

¹Ph. D. Program in Humanics, University of Tsukuba, Tsukuba, Japan, ²International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan, ³Department of Neuroscience, The Jikei University School of Medicine, Tokyo, Japan, ⁴Bruker Japan K.K., Yokohama, Japan, ⁵Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, ⁶Faculty of Engineering,, University of Tsukuba, Tsukuba, Japan

Synopsis

Keywords: fMRI, fMRISimultaneous recording of fMRI and EEG is a promising approach to realize functional brain imaging with high temporal and spatial resolution. However, using standard echo planar imaging in conventional fMRI studies, implantation of electrodes on the cortical surface induces strong magnetic susceptibility artifacts in fMRI images. The zero-echo time (ZTE) sequences show a remarkable reduction in sensitivity to magnetic susceptibility artifacts and motion-derived artifacts. In this study, we showed that the ZTE sequence suppressed the susceptibility artifact by electrodes and air in the ear canal in mice. Furthermore, ZTE showed the typical functional connectivity in the mice at resting state.

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